Critical illness myopathy in intensive care patients: Pathogenetic concepts and clinical management = "Critical illness myopathy" bei intensivpatienten: Pathogenetische konzepte und klinisches management

Friedrich, O. and Hund, E. (2006) Critical illness myopathy in intensive care patients: Pathogenetic concepts and clinical management = "Critical illness myopathy" bei intensivpatienten: Pathogenetische konzepte und klinisches management. Der Anaesthesist, 55 12: 1271-1280. doi:10.1007/s00101-006-1100-x


Author Friedrich, O.
Hund, E.
Title Critical illness myopathy in intensive care patients: Pathogenetic concepts and clinical management = "Critical illness myopathy" bei intensivpatienten: Pathogenetische konzepte und klinisches management
Journal name Der Anaesthesist   Check publisher's open access policy
ISSN 0003-2417
1432-055X
1437-4943
Publication date 2006-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00101-006-1100-x
Volume 55
Issue 12
Start page 1271
End page 1280
Total pages 10
Editor K. Peter
R. Larsen
Place of publication Berlin, Germany
Publisher Springer-Verlag
Language ger
Subject 1103 Clinical Sciences
Formatted abstract
Intensive care patients are at increased risk of developing sepsis with multi-organ failure during treatment (severe sepsis) possibly leading to complications of the central and peripheral nervous system. Among these, septic encephalopathy, critical illness polyneuropathy (CIP) and critical illness myopathy (CIM) are the most important. Neuromuscular complications in particular are difficult to diagnose as they mostly become apparent only when sedation has ceased and the awakening patient experiences difficulties in weaning from the respirator and reduced voluntary strength. CIP and CIM are generally self-limiting, however, they greatly prolong ICU stay and rehabilitation, thus nowadays also imposing a real budget threat. The diagnostics, especially the differentiation between CIM and CIP is difficult and a multi-disciplinary approach involving ICU physicians, anesthetists and neurologists is needed. Our knowledge of the causes of the primary ICU myopathy, although rapidly evolving during recent years, is still in its infancy and specific treatment of CIM is not yet available. The present overview summarizes insights into clinical and new diagnostic strategies for early detection of neuromuscular dysfunction in ICU patients. This article focuses on current concepts and results revealing the pathomechanism(s) of CIM and some simple therapeutic or preventive measures have been deduced which are summarized and discussed.
© 2006 Springer Medizin Verlag.
Keyword Myopathy
Critical illness
Pathomechanisms
Insulin therapy
Antioxidative capacity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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