Depolarisation of the plasma membrane in the arsenic trioxide (As 2O3)-and anti-CD95-induced apoptosis in myeloid cells

Nolte, Florian, Friedrich, Oliver, Rojewski, Markus, Fink, Rainer H. A., Schrezenmeier, Hubert and Körpe, Sixten (2004) Depolarisation of the plasma membrane in the arsenic trioxide (As 2O3)-and anti-CD95-induced apoptosis in myeloid cells. FEBS Letters, 578 1-2: 85-89. doi:10.1016/j.febslet.2004.10.075


Author Nolte, Florian
Friedrich, Oliver
Rojewski, Markus
Fink, Rainer H. A.
Schrezenmeier, Hubert
Körpe, Sixten
Title Depolarisation of the plasma membrane in the arsenic trioxide (As 2O3)-and anti-CD95-induced apoptosis in myeloid cells
Formatted title
Depolarisation of the plasma membrane in the arsenic trioxide (As 2O3)-and anti-CD95-induced apoptosis in myeloid cells
Journal name FEBS Letters   Check publisher's open access policy
ISSN 0014-5793
1873-3468
Publication date 2004-12-03
Sub-type Article (original research)
DOI 10.1016/j.febslet.2004.10.075
Volume 578
Issue 1-2
Start page 85
End page 89
Total pages 5
Editor F. Wieland
Place of publication Netherlands
Publisher Elsevier
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
Depolarisation of the plasma membrane has been shown to be actively regulated during lymphocyte-apoptosis. Here, we present data about anti-Fas and As2O3 induced depolarisation of myeloid U-937 cells. Anti-Fas but not As2O3-induced depolarisation was significantly dependent on caspase-activation. Na+-fluxes contributed to the depolarisation in early stages of As2O3-induced apoptosis, whereas the membrane potential in late stages depended on Cl --fluxes. Cl--channels also played an important role in the induction of cell shrinkage in As2O3-induced apoptosis. However, none of these ions contributed significantly to anti-Fas induced depolarisation. This indicates the existence of different mechanisms for apoptotic plasma membrane depolarisation within one cell type.
© 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Keyword Arsenic trioxide
Fas
Membrane potential
Apoptosis
Chloride channel
Q-Index Code C1
Additional Notes Referred to by: Corrigendum to: Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)- and anti-CD95-induced apoptosis in myeloid cells (FEBS 29005) [FEBS Letters 578 (2004) 85–89] FEBS Letters, Volume 579, Issue 17, 4 July 2005, Page 3866, Florian Nolte, Oliver Friedrich, Markus Rojewski, Rainer H.A. Fink, Hubert Schrezenmeier, Sixten Körper

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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