Dscam2 mediates axonal tiling in the Drosophila visual system

Millard, S. S., Flanagan, J. J., Pappu, K. S., Wu, W. and Zipursky, S. L. (2007) Dscam2 mediates axonal tiling in the Drosophila visual system. Nature, 447 7145: 720-724. doi:10.1038/nature05855

Author Millard, S. S.
Flanagan, J. J.
Pappu, K. S.
Wu, W.
Zipursky, S. L.
Title Dscam2 mediates axonal tiling in the Drosophila visual system
Formatted title
Dscam2 mediates axonal tiling in the Drosophila visual system
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
Publication date 2007-06-07
Sub-type Article (original research)
DOI 10.1038/nature05855
Volume 447
Issue 7145
Start page 720
End page 724
Total pages 5
Editor Philip Campbell
Nick Campbell
Place of publication London, U. K.
Publisher Nature Publishing Group
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
Sensory processing centres in both the vertebrate and the invertebrate brain are often organized into reiterated columns, thus facilitating an internal topographic representation of the external world. Cells within each column are arranged in a stereotyped fashion and form precise patterns of synaptic connections within discrete layers. These connections are largely confined to a single column, thereby preserving the spatial information from the periphery. Other neurons integrate this information by connecting to multiple columns. Restricting axons to columns is conceptually similar to tiling. Axons and dendrites of neighbouring neurons of the same class use tiling to form complete, yet non-overlapping, receptive fields. It is thought that, at the molecular level, cell-surface proteins mediate tiling through contact-dependent repulsive interactions, but proteins serving this function have not yet been identified. Here we show that the immunoglobulin superfamily member Dscam2 restricts the connections formed by L1 lamina neurons to columns in the Drosophila visual system. Our data support a model in which Dscam2 homophilic interactions mediate repulsion between neurites of L1 cells in neighbouring columns. We propose that Dscam2 is a tiling receptor for L1 neurons.
©2007 Nature Publishing Group.
Keyword Axons
Drosophila melanogaster
Drosophila proteins
Molecular sequence data
Protein Binding
Visual perception
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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