Dscam-mediated repulsion controls tiling and self-avoidance

Millard, S. Sean and Zipursky, S. Lawrence (2008) Dscam-mediated repulsion controls tiling and self-avoidance. Current Opinion In Neurobiology, 18 1: 84-89. doi:10.1016/j.conb.2008.05.005

Author Millard, S. Sean
Zipursky, S. Lawrence
Title Dscam-mediated repulsion controls tiling and self-avoidance
Journal name Current Opinion In Neurobiology   Check publisher's open access policy
ISSN 0959-4388
Publication date 2008-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.conb.2008.05.005
Volume 18
Issue 1
Start page 84
End page 89
Total pages 6
Editor Emilie Marcus
Place of publication London, U.K.
Publisher Elsevier
Language eng
Subject 1109 Neurosciences
Formatted abstract
Recent studies have uncovered the molecular basis of self-avoidance and tiling, two fundamental principles required for the formation of neural circuits. Both of these wiring strategies are established through homophilic repulsion between Dscam proteins expressed on opposing cell surfaces. In Drosophila, Dscam1 mediates self-avoidance, whereas Dscam2 mediates tiling. By contrast, phenotypes in the retina of the DSCAM mutant mouse indicate that DSCAM functions in both self-avoidance and tiling. These findings suggest that homophilic recognition molecules that have classically been defined as adhesive may also function as repulsive cues and that Dscam proteins specialize in this function.
© 2008 Elsevier Ltd. All rights reserved.
Keyword Cell communication
Cell differentiation
Drosophila melanogaster
Drosophila proteins
Nervous system
Neural pathways
Cell surface receptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 33 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 06 Apr 2010, 10:43:35 EST by June Temby on behalf of Faculty of Science