Dscam-mediated cell recognition regulates neural circuit formation

Hattori, D., Millard, S. S., Wojtowicz, W. M. and Zipursky, S. L. (2008) Dscam-mediated cell recognition regulates neural circuit formation. Annual Review of Cell And Developmental Biology, 24 597-620. doi:10.1146/annurev.cellbio.24.110707.175250

Author Hattori, D.
Millard, S. S.
Wojtowicz, W. M.
Zipursky, S. L.
Title Dscam-mediated cell recognition regulates neural circuit formation
Journal name Annual Review of Cell And Developmental Biology   Check publisher's open access policy
ISSN 1081-0706
ISBN 978-0-8243-3124-5
Publication date 2008-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1146/annurev.cellbio.24.110707.175250
Volume 24
Start page 597
End page 620
Total pages 24
Editor Randy Schekman
Place of publication Palo Alto, CA., U.S.A.
Publisher Annual Reviews
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
The Dscam family of immunoglobulin cell surface proteins mediates recognition events between neurons that play an essential role in the establishment of neural circuits. The Drosophila Dscam1 locus encodes tens of thousands of cell surface proteins via alternative splicing. These isoforms exhibit exquisite isoform-specific binding in vitro that mediates homophilic repulsion in vivo. These properties provide the molecular basis for self-avoidance, an essential developmental mechanism that allows axonal and dendritic processes to uniformly cover their synaptic fields. In a mechanistically similar fashion, homophilic repulsion mediated by Drosophila Dscam2 prevents processes from the same class of cells from occupying overlapping synaptic fields through a process called tiling. Genetic studies in the mouse visual system support the view that vertebrate DSCAM also promotes both self-avoidance and tiling. By contrast, DSCAM and DSCAM-L promote layer-specific targeting in the chick visual system, presumably through promoting homophilic adhesion. The fly and mouse studies underscore the importance of homophilic repulsion in regulating neural circuit assembly, whereas the chick studies suggest that DSCAM proteins may mediate a variety of different recognition events during wiring in a context-dependent fashion.
Copyright © 2008 by Annual Reviews. All rights reserved.
Keyword Self-avoidance
Immunoglobulin domain
Homophilic repulsion
Binding specificity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 83 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 06 Apr 2010, 09:56:56 EST by June Temby on behalf of Faculty of Science