Perforin: More than just a pore-forming protein

Zhou, Fang (2010) Perforin: More than just a pore-forming protein. International Reviews of Immunology, 29 1: 56-76. doi:10.3109/08830180903349644

Author Zhou, Fang
Title Perforin: More than just a pore-forming protein
Journal name International Reviews of Immunology   Check publisher's open access policy
ISSN 0883-0185
Publication date 2010-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/08830180903349644
Volume 29
Issue 1
Start page 56
End page 76
Total pages 21
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2011
Language eng
Formatted abstract
Cellular apoptosis induced by T cells is mainly mediated by two pathways.
One, granule exocytosis utilizes perforin/granzymes. The other involves signaling
through death receptors of the TNF-alphaR super-family, especially FasL. Perforin
plays a central role in apoptosis induced by granzymes. However, the mechanisms
of perforin-mediated cytotoxicity are still not elucidated completely. Perforin is not
only a pore-forming protein, but also performs multiple biological functions or perforin
performs one biological function (cytolysis), but has multiple biological implications
in the cellular immune responses, including regulation of proliferation of
CD8+ CTLs.
Copyright © Informa UK Ltd.
Keyword Perforin
NK cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 04 Apr 2010, 00:04:23 EST