A comparison of methods for assessing total arterial compliance

Haluska, B. A., Jeffriess, L., Brown, J., Carlier, S. and Marwick, T. H. (2010) A comparison of methods for assessing total arterial compliance. Journal of Human Hypertension, 24 4: 254-262. doi:10.1038/jhh.2009.92

Author Haluska, B. A.
Jeffriess, L.
Brown, J.
Carlier, S.
Marwick, T. H.
Title A comparison of methods for assessing total arterial compliance
Journal name Journal of Human Hypertension   Check publisher's open access policy
ISSN 0950-9240
Publication date 2010-04
Sub-type Article (original research)
DOI 10.1038/jhh.2009.92
Volume 24
Issue 4
Start page 254
End page 262
Total pages 9
Place of publication Houndmills, Basingstoke, Hampshire, U.K.
Publisher Nature Publishing Group
Collection year 2011
Language eng
Formatted abstract
There are several methods of assessing total arterial compliance (TAC) based on the two element Windkessel model, which is a ratio of pressure and volume, but the optimal technique is unclear. In this study, three methods of estimating TAC were compared to determine which was the most robust in a large group of patients with and without cardiovascular risk. In all, 320 patients (170 men; age 55±10) were studied; TAC was determined by the pulse-pressure method (PPM), the area method (AM) and the stroke volume/pulse-pressure method (SVPP). We obtained arterial waveforms using radial applanation tonometry, dimensions using two-dimensional echocardiography and flow data by Doppler. Clinical data, risk factors, echo parameters and TAC by all three methods were then compared. TAC (ml mm Hg–1) by the PPM was 1.24±0.51, by the AM 1.84±0.90 and by the SVPP 1.96±0.76 (P<0.0001 between groups). Correlation was good between all methods: PPM/AM r=0.83, PPM/SVPP r=0.94 and AM/SVPP r=0.80 (all P<0.0001). Subgroup analysis showed significant differences between patients with and those without cardiovascular risk for all three methods; TAC–AM and TAC–SVPP values were similar and significantly higher than TAC–PPM. The only significant relationships observed with TAC and echo parameters were in left ventricular (LV) septal thickness (R2=0.07; P<0.0001) and LV mass (R2=0.04; P=0.004). Normal and abnormal values of TAC vary according to method, which should be expressed. Each of the techniques shows good correlation with each other, however, values for TAC–PPM are significantly lower. TAC–PPM and TAC–SVPP are comparable in determining differences between groups with and without cardiovascular risk.
Keyword Total arterial compliance
Pulse-pressure method
Cardiovascular risk
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 04 Apr 2010, 00:03:31 EST