Axon guidance by growth-rate modulation

Mortimer, D, Pujic, Z, Vaughan, T, Thompson, AW, Feldner, J, Vetter, I and Goodhill, GJ (2010) Axon guidance by growth-rate modulation. Proceedings of the National Academy of Sciences of the United States of America, 107 11: 5202-5207. doi:10.1073/pnas.0909254107

Author Mortimer, D
Pujic, Z
Vaughan, T
Thompson, AW
Feldner, J
Vetter, I
Goodhill, GJ
Title Axon guidance by growth-rate modulation
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
Publication date 2010-03-01
Sub-type Article (original research)
DOI 10.1073/pnas.0909254107
Open Access Status Not Open Access
Volume 107
Issue 11
Start page 5202
End page 5207
Total pages 6
Place of publication Washington, United States
Publisher National Academy of Sciences
Collection year 2011
Language eng
Abstract Guidance of axons by molecular gradients is crucial for wiring up the developing nervous system. It often is assumed that the unique signature of such guidance is immediate and biased turning of the axon tip toward orawayfrom the gradient. However,hereweshow that such turning is not required for guidance. Rather, by a combination of experimental and computational analyses, we demonstrate that growth-rate modulation is an alternative mechanism for guidance. Furthermore we show that, although both mechanisms may operate simultaneously, biased turning dominates in steep gradients, whereas growth-rate modulation may dominate in shallow gradients. These results suggest that biased axon turning is not the only method by which guidance can occur.
Keyword Chemotaxis
Growth cone
Nerve growth factor
Neural development
Computational neuroscience
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2011 Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 38 times in Scopus Article | Citations
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Created: Sun, 04 Apr 2010, 00:01:24 EST