Sulfate and phosphate transporters in mammalian renal and gastrointestinal systems

Markovich, Daniel (2010). Sulfate and phosphate transporters in mammalian renal and gastrointestinal systems. In George A Gerencser (Ed.), Epithelial transport physiology (pp. 165-193) New York, U.S.A.: Humana Press. doi:10.1007/978-1-60327-229-2_8

Author Markovich, Daniel
Title of chapter Sulfate and phosphate transporters in mammalian renal and gastrointestinal systems
Title of book Epithelial transport physiology
Place of Publication New York, U.S.A.
Publisher Humana Press
Publication Year 2010
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-60327-229-2_8
Year available 2009
ISBN 9781603272285; 603272283; 9781603272292; 1603272291
Editor George A Gerencser
Chapter number 8
Start page 165
End page 193
Total pages 29
Total chapters 16
Collection year 2010
Language eng
Subjects B1
920106 Endocrine Organs and Diseases (excl. Diabetes)
060110 Receptors and Membrane Biology
Abstract/Summary This chapter will summarize the most recent data available for sulfate and phosphate transport in mammalian renal and gastrointestinal systems. Dietary derived sulfate and phosphate are absorbed in the intestines and their circulating levels are controlled by renal tubular mechanisms. Such processes are facilitated by sulfate and phosphate transporters that exist in the epithelial cells of the kidneys and intestines. Sulfate transporters belong to two gene families, the Na+-coupled sulfate transporters (SLC13) and the sulfate anion exchangers (SLC26). Phosphate transporters belong to three gene families, Type I (SLC17), Type II (SLC34), and Type III (SLC20) of which all members are Na+-coupled phosphate transporters. Tissue distribution for these transporters is diverse, with some being restricted to either renal or intestinal tissues and with others showing more broad tissue distribution. Various modes of regulation affect the expression of these genes and the proteins they encode in their respective tissues. Lessons from knock-out mice reveal the physiological (and pathophysiological) roles these proteins play in the body and their contributions to sulfate and phosphate homeostasis
Keyword Sulfate
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 01 Apr 2010, 13:59:04 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences