Ross River virus: molecular and cellular aspects of disease pathogenesis

Rulli, Nestor E., Suhrbier, Andreas, Hueston, Linda, Heise, Mark T., Tupanceska, Daniela, Zaid, Ali, Wilmes, Anja, Gilmore, Wilmese, Kerry, Lidbury, Brett A. and Mahalingam, Surendran (2005) Ross River virus: molecular and cellular aspects of disease pathogenesis. Pharmacology and Therapeutics, 107 3: 329-342. doi:10.1016/j.pharmthera.2005.03.006

Author Rulli, Nestor E.
Suhrbier, Andreas
Hueston, Linda
Heise, Mark T.
Tupanceska, Daniela
Zaid, Ali
Wilmes, Anja
Gilmore, Wilmese, Kerry
Lidbury, Brett A.
Mahalingam, Surendran
Title Ross River virus: molecular and cellular aspects of disease pathogenesis
Journal name Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0163-7258
Publication date 2005-09
Sub-type Article (original research)
DOI 10.1016/j.pharmthera.2005.03.006
Volume 107
Issue 3
Start page 329
End page 342
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 11 Medical and Health Sciences
1115 Pharmacology and Pharmaceutical Sciences
Abstract Ross River virus (RRV) is a mosquito-borne alphavirus indigenous to Australia and the Western Pacific region and is responsible for several thousand cases of human RRV disease (RRVD) per annum. The disease primarily involves polyarthritis/arthralgia, with many patients also presenting with rash, myalgia, fever, and/or lethargy. The symptoms can be debilitating at onset, but they usually resolve within 3-6 months. Recent insights into the RRV-host relationship, associated pathology, and molecular biology of infection have generated a number of potential avenues for improved treatment. Although vaccine development has been proposed, the small market size and potential for antibody-dependent enhancement (ADE) of disease make this approach unattractive. Recent insights into the molecular basis of RRV-ADE and the virus's ability to manipulate host inflammatory and immune responses create potential new opportunities for therapeutic invention. Such interventions should overcome virus-induced dysregulation of protective host responses to promote viral clearance and/or ameliorate inflammatory immunopathology.
Keyword Ross River virus
Antibody dependent enhancement of infection
Viral persistence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Thu, 01 Apr 2010, 10:20:32 EST by Therese Egan on behalf of Faculty Of Health Sciences