Two families of Rep-like genes that probably originated by interspecies recombination are represented in viral, plasmid, bacterial, and parasitic protozoan

Gibbs, Mark J., Smeianov, Vladimir V., Steele, James L, Upcroft, Peter and Efimov, Boris A. (2006) Two families of Rep-like genes that probably originated by interspecies recombination are represented in viral, plasmid, bacterial, and parasitic protozoan. Molecular Biology and Evolution, 23 6: 1097-1100. doi:10.1093/molbev/msj122


Author Gibbs, Mark J.
Smeianov, Vladimir V.
Steele, James L
Upcroft, Peter
Efimov, Boris A.
Title Two families of Rep-like genes that probably originated by interspecies recombination are represented in viral, plasmid, bacterial, and parasitic protozoan
Journal name Molecular Biology and Evolution   Check publisher's open access policy
ISSN 0737-4038
Publication date 2006
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1093/molbev/msj122
Volume 23
Issue 6
Start page 1097
End page 1100
Total pages 4
Place of publication United States
Publisher Oxford University Press
Language eng
Subject 06 Biological Sciences
0604 Genetics
Abstract Two families of genes related to, and including, rolling circle replication initiator protein (Rep) genes were defined by sequence similarity and by evidence of intergene family recombination. The Rep genes of circoviruses were the best characterized members of the "RecRep1 family." Other members of the RecRep1 family were Rep-like genes found in the genomes of the Canarypox virus, Entamoeba histolytica, and Giardia duodenalis and in a plasmid, p4M, from the Gram-positive bacterium, Bifidobacterium pseudocatenulatum. The "RecRep2 family" comprised some previously identified Rep-like genes from plasmids of phytoplasmas and similar Rep-like genes from the genomes of Lactobacillus acidophilus, Lactococcus lactis, and Phytoplasma asteris. Both RecRep1 and RecRep2 proteins have a nucleotide-binding domain significantly similar to the helicases (2C proteins) of picorna-like viruses. On the N-terminal side of the nucleotide binding domain, RecRep1 proteins have a domain significantly similar to one found in nanovirus Reps, whereas RecRep2 proteins have a domain significantly similar to one in the Reps of pLS1 plasmids. We speculate that RecRep genes have been transferred from viruses or plasmids to parasitic protozoan and bacterial genomes and that Rep proteins were themselves involved in the original recombination events that generated the ancestral RecRep genes.
Keyword Interspecies recombination
Gene family
Circovirus
RecRep1
pLS1 plasmid
Parasitic protozoan
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Thu, 01 Apr 2010, 09:08:33 EST by Therese Egan on behalf of Faculty Of Health Sciences