Interaction of human papillomaviruses with the host immune system: A well evolved relationship

Frazer, Ian (2009) Interaction of human papillomaviruses with the host immune system: A well evolved relationship. Virology, 384 2: 410-414. doi:10.1016/j.virol.2008.10.004


Author Frazer, Ian
Title Interaction of human papillomaviruses with the host immune system: A well evolved relationship
Journal name Virology   Check publisher's open access policy
ISSN 0042-6822
Publication date 2009-02-20
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.virol.2008.10.004
Volume 384
Issue 2
Start page 410
End page 414
Total pages 5
Editor Lamb, R. A.
Place of publication United States
Publisher Academic Press
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920108 Immune System and Allergy
920102 Cancer and Related Disorders
1107 Immunology
1112 Oncology and Carcinogenesis
Abstract Human papillomavirus (HPV) infections are generally long lasting, and a host immune response to infection is hard to detect. Nevertheless immunocompromised subjects control HPV infection less well than those with intact immunity. Immune responses are best documented for the papillomavirus groups that cause evident human disease, particularly those responsible for anogenital cancers and genital warts. Humoral immunity to the viral capsid has been shown sufficient for protection against infection, while innate and adaptive cell mediated immunity appears important for eventual elimination of HPV infection. However, molecular and cellular mechanisms responsible for protection from and clearance of HPV infection are not completely established. (C) 2008 Elsevier Inc. All rights reserved.
Keyword papillomaviruses
humoral immunity
cellular immunity
vaccines
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Thu, 01 Apr 2010, 01:45:57 EST by Sarah Macaione on behalf of UQ Diamantina Institute