Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions

Davies, Mark R., Tran, Thanh N., McMillan, David J., Gardiner, Donald L., Currie, Bart J. and Sriprakash, Kadaba S. (2005) Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions. Microbes and Infection: A journal on infectious agents and host defenses, 7 9-10: 1128-1138. doi:10.1016/j.micinf.2005.03.018


Author Davies, Mark R.
Tran, Thanh N.
McMillan, David J.
Gardiner, Donald L.
Currie, Bart J.
Sriprakash, Kadaba S.
Title Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions
Journal name Microbes and Infection: A journal on infectious agents and host defenses   Check publisher's open access policy
ISSN 1286-4579
Publication date 2005-07
Sub-type Article (original research)
DOI 10.1016/j.micinf.2005.03.018
Volume 7
Issue 9-10
Start page 1128
End page 1138
Total pages 11
Place of publication France
Publisher Elsevier Masson
Language eng
Subject 06 Biological Sciences
0605 Microbiology
11 Medical and Health Sciences
1108 Medical Microbiology
Abstract Streptococcus dysgalactiae subsp. equisimilis (human group G streptococcus, GGS) is generally regarded as a commensal organism but can cause a spectrum of human diseases very similar to that caused by S. pyogenes (group A streptococcus, GAS). Lateral acquisition of genes between these two phylogenetically closely related species is well documented. However, the extent and mechanisms of lateral acquisitions is not known. We report here genomic subtraction between a pathogenic GGS isolate and a community GGS isolate and analyses of the gene sequences unique to the pathovar. Our results show that cross-species genetic transfers are common between GGS and two closely related human pathogens, GAS and the group B streptococcus. We also demonstrate that mobile genetic elements, such as phages and transposons, play an important role in the ongoing inter-species transfers of genetic traits between extant organisms in the community. Furthermore, lateral gene transfers between GAS and GGS may occur more frequently in geographical regions of high GAS endemicity. These observations may have important implications in understanding the epidemiology of streptococcal diseases in such regions.
Keyword Streptococcus dysgalactiae
Streptococcus pyogenes
Streptococcus agalactiae
Horizontal gene transfer
Mobile genetic elements
Streptococcal phages
Group G streptococcus
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Wed, 31 Mar 2010, 15:34:34 EST by Therese Egan on behalf of Faculty Of Health Sciences