Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum

Wang, Y., Fu, X., Mengzhi, S., Luo, X., Hou, X., Dessein, H., Jie, Z., Xin-Ling, Y., He, H., McManus, D. P., Li, Y., Dessein, A., Arnaud, V. and Li, J. (2008) Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum. The Journal of Infectious Diseases, 198 3: 418-426. doi:10.1086/588826


Author Wang, Y.
Fu, X.
Mengzhi, S.
Luo, X.
Hou, X.
Dessein, H.
Jie, Z.
Xin-Ling, Y.
He, H.
McManus, D. P.
Li, Y.
Dessein, A.
Arnaud, V.
Li, J.
Title Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2008
Sub-type Article (original research)
DOI 10.1086/588826
Volume 198
Issue 3
Start page 418
End page 426
Total pages 9
Editor Lee Powers
Place of publication Chicago, IL, U.S.A.
Publisher University of Chicago Press
Language eng
Subject 06 Biological Sciences
0605 Microbiology
11 Medical and Health Sciences
1108 Medical Microbiology
Abstract Schistosoma japonicum is the most pathogenic agent of hepatosplenic schistosomiasis. It causes fibrosis of the central (CentF) and peripheral (PerF) portal areas. We investigated whether CentF and PerF in Chinese fishermen infected with S. japonicum were associated with an abnormal production of cytokines and chemokines that, in experimental models, have been implicated in the regulation of fibrosis. METHODS: Cytokines were measured by enzyme-linked immunosorbent assay in cultures of peripheral blood mononuclear cells from 127 patients, after stimulation with S. japonicum egg antigens. Data were analyzed by logistic regression that included age, sex, number of treatment episodes, alcohol use, and exposure as covariates. RESULTS: CentF was associated with low levels of interleukin (IL)-10 (P= .0004), regulated on activation normally T cell expressed and secreted (P= .0004), and macrophage inflammatory protein-1alpha (P= .007). In a multivariate analysis, only IL-10 was associated with CentF (odds ratio [OR], 10.8; 95% confidence interval [CI], 3.2-38; P= .0004). Splenomegaly was also associated with low IL-10 production and, independently, with CentF. In multivariate analysis, PerF was associated with low production of interferon (IFN)-gamma (OR, 8.2; 95% CI, 2-33; P= .0035) but not with production of IL-10. CONCLUSIONS: IL-10 is associated with protection against central fibrosis, because of its anti-inflammatory and antifibrosis effects. IFN-gamma is associated with protection against PerF, which depends more on egg load and egg-associated toxicity.
Keyword Schistosoma japonicum
Hepatosplenic schistosomiasis
Chinese fishermen
Fibrosis
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Wed, 31 Mar 2010, 13:53:23 EST by Therese Egan on behalf of Faculty Of Health Sciences