Genomics of parasitic flatworms

McManus, Donald P., Le, Thanh Hoa and Blair, David (2004). Genomics of parasitic flatworms. In: International Journal for Parasitology. Proceedings of: Annual Scientific Meeting of the Australian Society for Parasitology. 45th Annual Scientific Meeting of the Australian Society for Parasitology, Darwin, Australia, (153-158). 6-10 July, 2003. doi:10.1016/j.ijpara.2003.11.003


Author McManus, Donald P.
Le, Thanh Hoa
Blair, David
Title of paper Genomics of parasitic flatworms
Conference name 45th Annual Scientific Meeting of the Australian Society for Parasitology
Conference location Darwin, Australia
Conference dates 6-10 July, 2003
Proceedings title International Journal for Parasitology. Proceedings of: Annual Scientific Meeting of the Australian Society for Parasitology   Check publisher's open access policy
Journal name International Journal for Parasitology   Check publisher's open access policy
Place of Publication Oxford, U.K.
Publisher Pergamon-Elsevier Science. Australian Society for Parasitology
Publication Year 2004
Year available 2003
Sub-type Fully published paper
DOI 10.1016/j.ijpara.2003.11.003
ISSN 0020-7519
1879-0135
Volume 34
Issue 2
Start page 153
End page 158
Total pages 6
Language eng
Formatted Abstract/Summary
Although we live in what is often touted as the ‘post-genomic era’, this term is hardly appropriate when we consider the paucity of knowledge of the genomic biology of parasitic flatworms. The situation is, however, changing—at least for two species of Schistosoma. Recent transcriptome analysis of Schistosoma mansoni and of Schistosoma japonicum has identified novel genes and genes not previously reported for schistosomes, as well as the identification of the molecular mechanisms for host-dependent maturation, immune evasion, development, signalling and sexual dimorphism. The analyses also identify potential vaccine candidates and drug targets. Here, the current state of knowledge is reviewed for mitochondrial and nuclear genomes of parasitic flatworms. We highlight the remarkable recent progress in gene discovery for schistosomes and the goal of sequencing complete schistosome genomes.
© 2003 Australian Society for Parasitology Inc.
Subjects 06 Biological Sciences
0605 Microbiology
Keyword Mitochondrial genome
Nuclear genome
Parasitic flatworms
Schistosoma mansoni
Schistosoma japonicum
Gene discovery
Q-Index Code E1

 
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Created: Wed, 31 Mar 2010, 12:12:01 EST by Therese Egan on behalf of Faculty Of Health Sciences