Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Barrett, Jeffrey C., Wellcome Trust Case Control Consortium, Brown, Matthew A., Bradbury, Linda A. and et al. (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics, 40 8: 955-962. doi:10.1038/ng.175


Author Barrett, Jeffrey C.
Wellcome Trust Case Control Consortium
Brown, Matthew A.
Bradbury, Linda A.
et al.
Title Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2008-08
Sub-type Article (original research)
DOI 10.1038/ng.175
Volume 40
Issue 8
Start page 955
End page 962
Total pages 8
Editor Myles Axton
Place of publication New York, U.K.
Publisher Nature America
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.
Copyright Nature Publishing Group.
Keyword Nonsynonymous SNPS
Genetic-variation
Variants
Cells
Expression
IL-23 gene–deficient mice
Colitis
risk
Multiple
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
UQ Diamantina Institute Publications
 
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Created: Wed, 31 Mar 2010, 11:53:20 EST by June Temby on behalf of UQ Diamantina Institute