Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease

Batzloff, Michael R., Pandey, Manisha, Olive, Colleen and Good, Michael F. (2006) Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease. Immunologic Research, 35 3: 233-248. doi:10.1385/IR:35:3:233


Author Batzloff, Michael R.
Pandey, Manisha
Olive, Colleen
Good, Michael F.
Title Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease
Journal name Immunologic Research   Check publisher's open access policy
ISSN 0257-277X
1559-0755
Publication date 2006-07
Sub-type Article (original research)
DOI 10.1385/IR:35:3:233
Volume 35
Issue 3
Start page 233
End page 248
Total pages 16
Place of publication United States
Publisher Humana Press
Language eng
Subject 11 Medical and Health Sciences
1107 Immunology
Abstract Rheumatic fever (RF) and rheumatic heart disease (RHD) are post-infectious complications of an infection (or repeated infection) with the Gram-positive bacterium Streptococcus pyogenes (also known as group A streptococcus, GAS). RF and RHD are global problems and affect many indigenous populations of developed countries and many developing countries. However, RF and RHD are only part of a larger spectrum of diseases caused by this organism. The development of a vaccine against GAS has primarily targeted the abundant cell-surface protein called the M-protein. This review focuses on different M-protein-based-subunit vaccine approaches and the different delivery technologies used to administer these vaccine candidates in preclinical studies.
Keyword Peptide
Lipid
Streptococcus
Antimicrobials
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Wed, 31 Mar 2010, 11:48:06 EST by Therese Egan on behalf of Faculty Of Health Sciences