Immune response to superoxide dismutase in group A streptococcal infection

McMillan, David J., Davies, Mark R., Good, Michael F. and Sriprakash, Kadaba S. (2004) Immune response to superoxide dismutase in group A streptococcal infection. FEMS Immunology and Medical Microbiology, 40 3: 249-256. doi:10.1016/S0928-8244(04)00003-3

Author McMillan, David J.
Davies, Mark R.
Good, Michael F.
Sriprakash, Kadaba S.
Title Immune response to superoxide dismutase in group A streptococcal infection
Journal name FEMS Immunology and Medical Microbiology   Check publisher's open access policy
ISSN 0928-8244
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/S0928-8244(04)00003-3
Volume 40
Issue 3
Start page 249
End page 256
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 11 Medical and Health Sciences
1108 Medical Microbiology
Abstract Extracellular localisation of manganese-dependent superoxide dismutase (SodA) by group A streptococcus (GAS) may have a role in protection of this pathogenic bacterium from exogenously produced reactive oxygen species. In this study we show that SodA is found both in surface protein extracts and in culture supernatants of GAS. To investigate whether SodA is a possible vaccine candidate outbred Quackenbush mice were subcutaneously vaccinated with recombinant SodA. Strong antibody responses which were moderately opsonic were elicited. These antibodies were unable to protect mice from intraperitoneal challenge with M1 GAS. We also show that SodA and p145 (a conserved peptide from the M-protein) antibodies are present at significantly higher levels amongst patients with rheumatic heart disease than in control subjects from the same endemic region. The higher SodA antibody levels in patients may be indicative of a role for this protein in pathogenesis of rheumatic heart disease but are more likely to be a marker of recent or recurrent streptococcal infection.
Keyword Group A streptococcus
Superoxide dismutase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes First published online 26 January 2004.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Wed, 31 Mar 2010, 11:40:59 EST by Therese Egan on behalf of Faculty Of Health Sciences