Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Barton, Anne, Wellcome Trust Case Control Consortium, Brown, Matthew A., Bradbury, Linda A. and et al. (2008) Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics, 40 10: 1156-1159. doi:10.1038/ng.218


Author Barton, Anne
Wellcome Trust Case Control Consortium
Brown, Matthew A.
Bradbury, Linda A.
et al.
Title Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2008-10
Sub-type Article (original research)
DOI 10.1038/ng.218
Volume 40
Issue 10
Start page 1156
End page 1159
Total pages 4
Editor Myles Axton
Place of publication New York, U.S.A.
Publisher Nature America
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 × 10^sup -4^ - 1 × 10^sup -5^ (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 × 10^sup -5^, P = 4 × 10^sup -4^ and P = 4 × 10^sup -4^, respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
Copyright Nature Publishing Group.
Keyword Genome-wide Association
Expression
Pathway
6Q23
Risk
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
UQ Diamantina Institute Publications
 
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