Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Ferreira, Manuel A. R., Welcome Trust Case Control Consortium, Brown, Matthew A., Bradbury, Linda A. and et al. (2008) Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature genetics, 40 9: 1056-1058. doi:10.1038/ng.209


Author Ferreira, Manuel A. R.
Welcome Trust Case Control Consortium
Brown, Matthew A.
Bradbury, Linda A.
et al.
Title Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Journal name Nature genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2008-09
Sub-type Article (original research)
DOI 10.1038/ng.209
Volume 40
Issue 9
Start page 1056
End page 1058
Total pages 3
Editor Myles Axton
Place of publication New York, U.S.A.
Publisher Nature America Inc
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10^sup -9^) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 × 10^sup -8^, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
Copyright Nature Publishing Group.
Keyword ank3 gene
Bipolar disorder
CACNA1C gene
Genome analysis
Ankyrins
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 609 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 649 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 31 Mar 2010, 09:02:16 EST by June Temby on behalf of Institute for Molecular Bioscience