Control of scabies, skin sores and haematuria in children in the Solomon Islands: Another role for ivermectin

Lawrence, Gregor, Leafasia, Judson, Sheridan, John, Hills, Susan, Wate, Janet, Wate, Christine, Montgomery, Janet, Pandeya, Nirmala and Purdie, David (2005) Control of scabies, skin sores and haematuria in children in the Solomon Islands: Another role for ivermectin. Bulletin of the World Health Organization, 83 1: 34-42.

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Author Lawrence, Gregor
Leafasia, Judson
Sheridan, John
Hills, Susan
Wate, Janet
Wate, Christine
Montgomery, Janet
Pandeya, Nirmala
Purdie, David
Title Control of scabies, skin sores and haematuria in children in the Solomon Islands: Another role for ivermectin
Journal name Bulletin of the World Health Organization   Check publisher's open access policy
ISSN 0042-9686
Publication date 2005-01
Year available 2005
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 83
Issue 1
Start page 34
End page 42
Total pages 9
Place of publication Geneva, Switzerland
Publisher World Health Organisation
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
Formatted abstract
To assess the effects of a 3-year programme aimed at controlling scabies on five small lagoon islands in the Solomon Islands by monitoring scabies, skin sores, streptococcal skin contamination, serology and haematuria in the island children.


Control was achieved by treating almost all residents of each island once or twice within 2 weeks with ivermectin (160–250 ug/kg), except for children who weighed less than 15 kg and pregnant women, for whom 5% permethrin cream was used. Reintroduction of scabies was controlled by treating returning residents and visitors, whether or not they had evident scabies.


Prevalence of scabies dropped from 25% to less than 1% (P < 0.001); prevalence of sores from 40% to 21% (P < 0.001); streptococcal contamination of the fingers in those with and without sores decreased significantly (P = 0.02 and 0.047, respectively) and anti-DNase B levels decreased (P = 0.002). Both the proportion of children with haematuria and its mean level fell (P = 0.002 and P < 0.001, respectively). No adverse effects of the treatments were seen.


The results show that ivermectin is an effective and practical agent in the control of scabies and that control reduces the occurrence of streptococcal skin disease and possible signs of renal damage in children. Integrating community-based control of scabies and streptococcal skin disease with planned programmes for controlling filariasis and intestinal nematodes could be both practical and produce great health benefits.
Keyword Scabies
Infectious diesase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Created: Tue, 30 Mar 2010, 15:19:16 EST by Therese Egan on behalf of Faculty Of Health Sciences