A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China

Li, Yue-Sheng, Chen, Hong-Gen, He, Hong-Bin, Hou, Xu-Yua, Ellis, Magda and McManus, Donald P. (2005) A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China. Acta Tropica, 96 2-3: 184-190. doi:10.1016/j.actatropica.2005.07.013


Author Li, Yue-Sheng
Chen, Hong-Gen
He, Hong-Bin
Hou, Xu-Yua
Ellis, Magda
McManus, Donald P.
Title A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China
Journal name Acta Tropica   Check publisher's open access policy
ISSN 0001-706X
1873-6254
Publication date 2005-11
Sub-type Article (original research)
DOI 10.1016/j.actatropica.2005.07.013
Volume 96
Issue 2-3
Start page 184
End page 190
Total pages 7
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
Abstract To further strengthen the evidence-base of artemether for the control of schistosomiasis japonica, a randomised controlled trial was carried out in the Poyang Lake region, a highly endemic area in southern China. A total of 783 individuals, aged 6–60 years, were enrolled. They were first given a single oral dose of praziquantel (50 mg/kg). Then, they were randomly assigned oral artemether (6 mg/kg) or placebo, administered once every 2 weeks for 9–11 doses, covering the entire transmission season for Schistosoma japonicum in 2004. Stool examination 1 month after the final dosing revealed eggs of S. japonicum in 3/373 (0.8%) of the artemether recipients and 56/361 (15.0%) in placebo recipients (χ2 = 53.69, P < 0.001). Compared to the baseline, the geometric mean intensity of S. japonicum infection had decreased by 96.1% in the artemether group, and increased by 50.8% in the placebo group. No acute cases of schistosomiasis japonica were observed in the artemether group, whereas three such cases were reported from the placebo group. Compliance with regard to multi-doses of artemether and placebo was 84.9, and 77.9%, respectively. This study confirms that repeated oral artemether produces no drug-related adverse effects, significantly reduces incidence and intensity of patent S. japonicum infection and results in high compliance. Hence it can be used as an additional tool for the control of schistosomiasis japonica in the lake regions of China.
Keyword Schistosomiasis japonica
Schistosoma japonicum
Artemether
Praziquantel
Randomised controlled trial
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Tue, 30 Mar 2010, 12:59:51 EST by Therese Egan on behalf of Faculty Of Health Sciences