Suppression of antiviral responses by antibody-dependent enhancement of macrophage infection

Suhrbier, Andreas and Linn, May La (2003) Suppression of antiviral responses by antibody-dependent enhancement of macrophage infection. Trends in Immunology, 24 4: 165-168. doi:10.1016/S1471-4906(03)00065-6


Author Suhrbier, Andreas
Linn, May La
Title Suppression of antiviral responses by antibody-dependent enhancement of macrophage infection
Journal name Trends in Immunology   Check publisher's open access policy
ISSN 1471-4906
Publication date 2003-04
Sub-type Article (original research)
DOI 10.1016/S1471-4906(03)00065-6
Volume 24
Issue 4
Start page 165
End page 168
Total pages 4
Publisher Elsevier
Language eng
Subject 1107 Immunology
11 Medical and Health Sciences
Abstract Antibody-dependent enhancement (ADE) of macrophage and monocyte infection has been demonstrated in vitro for some of the most deadly RNA viruses known. Recent evidence suggests that ADE-mediated ligation of Fc receptors might suppress host-cell antiviral gene expression by promoting early interleukin-10 (IL-10) secretion, resulting in the expression of suppressor-of-cytokine-signalling (SOCS) proteins and a Th2 bias. These findings provide potential new insights into how ADE might enhance viral infections and exacerbate disease.
Keyword RNA virus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 36 times in Scopus Article | Citations
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Created: Tue, 30 Mar 2010, 11:23:47 EST by Therese Egan on behalf of Faculty Of Health Sciences