Prioritising drugs for single patient (n-of-1) trials in palliative care

Nikles, J., Mitchell, G., Walters, J., Hardy, J., Good, P., Rowett, D., Shelby-James, T. and Currow, D. (2009) Prioritising drugs for single patient (n-of-1) trials in palliative care. Palliative Medicine, 23 7: 623-634. doi:10.1177/0269216309106461

Author Nikles, J.
Mitchell, G.
Walters, J.
Hardy, J.
Good, P.
Rowett, D.
Shelby-James, T.
Currow, D.
Title Prioritising drugs for single patient (n-of-1) trials in palliative care
Journal name Palliative Medicine   Check publisher's open access policy
ISSN 0269-2163
Publication date 2009-10
Sub-type Article (original research)
DOI 10.1177/0269216309106461
Volume 23
Issue 7
Start page 623
End page 634
Total pages 12
Place of publication London, United Kingdom
Publisher Sage Publications
Collection year 2010
Language eng
Subject C1
920211 Palliative Care
111707 Family Care
Abstract Many of the drugs prescribed commonly to palliative care patients have potentially significant side-effects and are of unproven benefit. The acquisition of evidence to support the prescribing of these drugs has been very slow. Single patient trials (SPTs) (also known as n-of-1 trials) offer a potential means of obtaining the evidence necessary to support or refute the use of several of the drugs and interventions whose use is currently based on physician experience or anecdote alone. A list of SPTs considered “most urgent”, for commonly employed treatments and for the most common and most troublesome symptoms in palliative care is presented. These are drugs for which the gap between evidence and practice is greatest, where the evidence of efficacy is most lacking, where significant side effects potentially lead to the greatest morbidity, or where cost is a major patient burden. Although not all the drugs used in palliative care are suitable, SPTs provide a potential alternative method of gathering evidence in palliative care.
Keyword Drug
N-of-1 trials
Palliative care
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Mon, 29 Mar 2010, 12:43:29 EST by Denise Wilson on behalf of Medicine - Mater Hospital