Molecular epidemiology of cystic echinococcosis

McManus, D. P. and Thompson, R. C. A. (2003) Molecular epidemiology of cystic echinococcosis. Parasitology, 127 Suppl. S: S37-S51. doi:10.1017/S0031182003003524


Author McManus, D. P.
Thompson, R. C. A.
Title Molecular epidemiology of cystic echinococcosis
Journal name Parasitology   Check publisher's open access policy
ISSN 0031-1820
1469-8161
Publication date 2003
Sub-type Article (original research)
DOI 10.1017/S0031182003003524
Volume 127
Issue Suppl. S
Start page S37
End page S51
Total pages 15
Place of publication United Kingdom
Publisher Cambridge Press
Language eng
Subject 06 Biological Sciences
0605 Microbiology
Abstract Echinococcus granulosus exhibits substantial genetic diversity that has important implications for the design and development of vaccines, diagnostic reagents and drugs effective against this parasite. DNA approaches that have been used for accurate identification of these genetic variants are presented here as is a description of their application in molecular epidemiological surveys of cystic echinococcosis in different geographical settings and host assemblages. The recent publication of the complete sequences of the mitochondrial (mt) genomes of the horse and sheep strains of E. granulosus and of E. multilocularis, and the availability of mt DNA sequences for a number of other E. granulosus genotypes, has provided additional genetic information that can be used for more in depth strain characterization and taxonomic studies of these parasites. This very rich sequence information has provided a solid molecular basis, along with a range of different biological, epidemiological, biochemical and other molecular-genetic criteria, for revising the taxonomy of the genus Echinococcus. This has been a controversial issue for some time. Furthermore, the accumulating genetic data may allow insight to several other unresolved questions such as confirming the occurrence and precise nature of the E. granulosus G9 genotype and its reservoir in Poland, whether it is present elsewhere, why the camel strain (G6 genotype) appears to affect humans in certain geographical areas but not others, more precise delineation of the host and geographic ranges of the genotypes characterised to date, and whether additional genotypes of E. granulosus remain to be identified.
Keyword Echinococcus granulosus
Echinococcus
Echinococcus multilocularis
Echinococcosis
Strain variation
Genotype
Horse-dog strain
Sheep-dog strain
Mitochondrial DNA
Cox1 gene
Nad1 gene
Taxonomy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Mon, 29 Mar 2010, 09:19:23 EST by Therese Egan on behalf of Faculty Of Health Sciences