Microarray-based gene set analysis in cancer studies

Dr Sarah Song (2008). Microarray-based gene set analysis in cancer studies PhD Thesis, Department of Statistics, The University of Auckland.


Author Dr Sarah Song
Thesis Title Microarray-based gene set analysis in cancer studies
School, Centre or Institute Department of Statistics
Institution The University of Auckland
Publication date 2008
Thesis type PhD Thesis
Supervisor Black, Michael
Total pages 219
Language eng
Abstract/Summary This work addresses the development and application of gene set analysis methods to problems in microarray-based data sets. The work consists of three parts. In the first part a gene set analysis method (PCOT2) is developed. It utilizes inter-gene correlation to detect significant alteration in gene sets across experimental conditions. The second part is focused on the exploration of correlation-based gene sets in conjunction with the application of the PCOT2 testing method in the investigation of biological mechanisms underlying breast cancer recurrence. In the third part, statistical models for analyzing combined microarray-based expression and genomic copy number data are developed. In addition, an analysis which incorporates tumour subgroups is shown to provide more accurate prognosis assessment for breast cancer patients.

 
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Created: Sun, 28 Mar 2010, 16:49:34 EST by Dr Sarah Song on behalf of School of Nursing, Midwifery and Social Work