Cardiac troponin may be released by ischemia alone, without necrosis

Hickman, Peter E., Potter, Julia M., Aroney, Con, Koerbin, Gus, Southcott, Emma, Wu, Alan H. B. and Roberts, Michael S. (2010) Cardiac troponin may be released by ischemia alone, without necrosis. Clinica Chimica Acta, 411 5-6: 318-323. doi:10.1016/j.cca.2009.12.009


Author Hickman, Peter E.
Potter, Julia M.
Aroney, Con
Koerbin, Gus
Southcott, Emma
Wu, Alan H. B.
Roberts, Michael S.
Title Cardiac troponin may be released by ischemia alone, without necrosis
Journal name Clinica Chimica Acta   Check publisher's open access policy
ISSN 0009-8981
1873-3492
Publication date 2010-03-02
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cca.2009.12.009
Open Access Status
Volume 411
Issue 5-6
Start page 318
End page 323
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2011
Language eng
Subject 920103 Cardiovascular System and Diseases
1102 Cardiovascular Medicine and Haematology
Abstract Whilst it is formally stated that cardiac troponin is only released when cardiac myocytes undergo necrosis, there are a number of clinical situations where troponin is present in the circulation, without any apparent cardiac injury. In these cases, troponin half-life in the circulation is usually substantially shorter than that seen when troponin is released following myocardial infarction with frank necrosis. A mechanism has been described in liver, where large cytoplasmic molecules can pass from the intra- to extra-cellular space without cellular necrosis occurring. This occurs by the formation of membranous blebs which bud off from the plasma membrane of the cell. Blebs develop during cellular ischemia. If the ischemia is limited and re-oxygenation occurs, the blebs may be released into the circulation without rupture of the plasma membrane, resulting in a one-off release of cytoplasmic contents including macromolecules. Evidence from cardiac studies is presented supporting the presence of membranous blebs in cardiac myocytes, enabling troponin to be released from cardiac cells due to ischemia alone, without necrosis. Copyright © 2009 Elsevier B.V. All rights reserved.
Keyword Troponin T
Troponin I
Blebs
Ischemia
Necrosis
Integrins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 28 December 2009.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 28 Mar 2010, 00:06:29 EST