Increased arterial stiffness in hemodialysis patients with end stage renal disease caused by diabetic nephropathy

Smith, Marianne, Anderson, Lisa, Sharman, James, Koh, Kirsten, Fassett, Robert and Coombes, Jeff (2007). Increased arterial stiffness in hemodialysis patients with end stage renal disease caused by diabetic nephropathy. In: Renal Society of Australasia National Conference 2007, Perth, (). 15-18 August 2007.


Author Smith, Marianne
Anderson, Lisa
Sharman, James
Koh, Kirsten
Fassett, Robert
Coombes, Jeff
Title of paper Increased arterial stiffness in hemodialysis patients with end stage renal disease caused by diabetic nephropathy
Conference name Renal Society of Australasia National Conference 2007
Conference location Perth
Conference dates 15-18 August 2007
Place of Publication Perth, W.A.
Publisher Renal Society of Australasia
Publication Year 2007
Sub-type Poster
Formatted Abstract/Summary
 Arterial stiffness has been shown to predict outcome in patients with end stage renal disease (ESRD). We investigated whether arterial stiffness was different between hemodialysis (HD) patients with ESRD caused by diabetic nephropathy (DN) compared with other causes. 39 HD patients are included in this study. There were no significant (P>0.05) differences between patients whose ESRD was caused by DN (n=12) compared to other causes (n=27) in respect to age (63 11 vs 55 18 yrs), time on dialysis (2.8 1.7 vs 3.5 1.9 yrs) and factors known, or thought to affect arterial stiffness and wave reflection such as sex (male = 50% vs 63%), height (168 13 vs 165 10 cm), resting heart rate (72.3 11.2 vs 73.5 11.0 bpm) and mean arterial pressure (107 15 vs 102 16 mm Hg). Radial artery pulse waveforms were obtained by using the SphygmoCor System (Atcor Medical, Sydney, Australia). Pulse wave velocity (PWV) between the radial and carotid arteries was measured using the same equipment. PWV was significantly (P<0.05) greater in patients with ESRD caused by DN compared to other causes (9.3 2.0 vs 8.0 1.7 m/s). Analysis of aortic wave forms showed that the reflected wave arrival time T(r) was significantly (P<0.05) slower in patients with DN (128.7 11.4 vs 136.9 10.7 m/s) further indicating increased arterial stiffness. In summary, in hemodialysis patients with ESRD caused by DN there is increased arterial stiffness suggesting that more aggressive therapy to address vascular protection should be undertaken in the early stages of DN.
Subjects 1103 Clinical Sciences
Keyword Patients
Renal Disease
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Fri, 26 Mar 2010, 14:37:41 EST by Ms May Balasaize on behalf of Faculty Of Health Sciences