Antimicrobial susceptibility of bacteria isolated from newborns with suspected or confirmed necrotising enterocolitis

Jardine, Luke Anthony, Cartwright, David, Inglis, Garry Trevor and Davies, Mark William (2009) Antimicrobial susceptibility of bacteria isolated from newborns with suspected or confirmed necrotising enterocolitis. Macedonian Journal of Medical Sciences, 2 4: 301-304. doi:10.3889/MJMS.1857-5773.2009.0071

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ200692_OA.pdf Full text (open access) application/pdf 455.16KB 0

Author Jardine, Luke Anthony
Cartwright, David
Inglis, Garry Trevor
Davies, Mark William
Title Antimicrobial susceptibility of bacteria isolated from newborns with suspected or confirmed necrotising enterocolitis
Journal name Macedonian Journal of Medical Sciences   Check publisher's open access policy
ISSN 1857-5749
1857-5773
Publication date 2009-12-15
Year available 2009
Sub-type Article (original research)
DOI 10.3889/MJMS.1857-5773.2009.0071
Open Access Status File (Publisher version)
Volume 2
Issue 4
Start page 301
End page 304
Total pages 4
Editor Jean Gogusev
Mirko Spiroski
Stojmir Petrov
Place of publication Macedonia
Publisher Univerzitet "Sv. Kiril i Metodij", Medicinski Fakultet
Collection year 2010
Language eng
Subject C1
920109 Infectious Diseases
110303 Clinical Microbiology
Abstract Aim. This audit aimed to identify which bacteria were associated with necrotising enterocolitis (NEC) and determine their antibiotic sensitivities. Methods. A retrospective audit of all infants with a diagnosis of suspected NEC or confirmed NEC and a positive culture (blood/faeces/operative specimen or vascular access device) between January 2000 and September 2007 was performed. Results. Ninety nine infants had a diagnosis of suspected (45) or confirmed NEC (54). Seventeen patients had suspected (5) or confirmed (12) NEC and a positive culture result. 12 babies had positive blood cultures associated with their NEC. Only 4 of the 12 cases of NEC with a positive blood culture received adequate first line cover for their subsequently identified infecting organism. Conclusions. Due to the limitations of this study we are unable to make general recommendations on the first line antibiotic choice for babies with suspected or confirmed NEC. Our current regime of Ampicillin, Gentamicin and Metronidazole failed to adequately treat 8 of the 12 organisms subsequently isolated in blood cultures. Only the combination of Vancomycin and Meropenem would have adequately treated all the bacteria identified. The concern with this approach is the possible emergence of multi drug resistant bacteria.
Keyword Blood cultures
Necrotising enterocolitis
Infant, Newborn
Infant, preterm
Antibacterial Agents
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 25 Mar 2010, 16:14:00 EST by Melanie Thomas on behalf of Paediatrics & Child Health - RBWH