The role of basic nutritional research in pediatric liver disease: An historical perspective

Cleghorn, Geoff (2009) The role of basic nutritional research in pediatric liver disease: An historical perspective. Journal of Gastroenterology and Hepatology, 24 s3: S93-S96. doi:10.1111/j.1440-1746.2009.06078.x


Author Cleghorn, Geoff
Title The role of basic nutritional research in pediatric liver disease: An historical perspective
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 0815-9319
1440-1746
Publication date 2009-10-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1440-1746.2009.06078.x
Volume 24
Issue s3
Start page S93
End page S96
Total pages 4
Editor Geoff Farrell
Place of publication Mulgrave, Victoria
Publisher Journal of Gastroenterology & Hepatology Foundation
Collection year 2010
Language eng
Abstract The advent of liver transplantation for end-stage liver disease (ESLD) in children has necessitated a major rethink in the preoperative preparation and management from simple palliative care to active directed intervention. This is particularly evident in the approach to the nutritional care of these patients with the historical understanding of the nutritional pertubations in ESLD being described from a single pediatric liver transplant center. ESLD in children is a hypermetabolic process adversely affecting nutritional status, metabolic, and non-metabolic body compartments. There is a complex dynamic process affecting metabolic activity within the metabolically active body cell mass, as well as lipid oxidation during fasting and at rest, with other factors operating in conjunction with daily activities. We have proposed that immediately ingested nutrients are a more important source of energy in patients with ESLD than in healthy children, among whom energy may be stored in various body compartments.
Keyword Branch chain amino acids
Energy expenditure
Nutrition
Survival
Total body potassium
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Thu, 25 Mar 2010, 15:32:09 EST by Jon Stekhoven on behalf of School of Medicine