Balancing immunity and pathology in visceral leishmaniasis

Stanley, Amanda C. and Engwerda, Christian R. (2007) Balancing immunity and pathology in visceral leishmaniasis. Immunology and Cell Biology, 85 2: 138-147. doi:10.1038/sj.icb7100011

Author Stanley, Amanda C.
Engwerda, Christian R.
Title Balancing immunity and pathology in visceral leishmaniasis
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
Publication date 2007-02
Year available 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/sj.icb7100011
Volume 85
Issue 2
Start page 138
End page 147
Total pages 10
Place of publication Basingstoke, U.K.
Publisher Nature Publishing Group
Language eng
Subject 1107 Immunology
Formatted abstract
Experimental visceral leishmaniasis (VL) caused by infection with Leishmania donovani results in the development of organ-specific immunity in the two main target tissues of infection, the spleen and the liver. The liver is the site of an acute resolving infection associated with the development of inflammatory granulomas around infected Kupffer cells, and resistance to reinfection. Paradoxically, the spleen is an initial site for the generation of cell-mediated immune responses, but ultimately becomes a site of parasite persistence with associated immunopathological changes. These include splenomegaly and a breakdown in tissue architecture that is postulated to contribute to the immunocompromized status of the host. The progressive development of splenic pathology is largely associated with high levels of TNF and interleukin (IL)-10. Follicular dendritic cell (DC) networks are lost, whereas TNF mediates the destruction of marginal zone macrophages and gp38+ stromal cells, and IL-10 promotes impaired DC migration into T-cell areas with consequent ineffective T-cell priming. Splenic stromal cell function is also altered, promoting the selective development of IL-10-producing DC with immunoregulatory properties. Ultimately, a fine immunological balance determines responses that effectively promote parasite clearance in the liver and those that promote pathology in the spleen, and future investigation aims to separate these responses to offer further means of parasite control in chronically infected VL patients.
© 2007 Australasian Society for Immunology Inc. All rights reserved
Keyword Leishmania
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Published online 5 December 2006. Published under "Special Feature on Immunopathology of Infectious Diseases: Part 2"

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Excellence in Research Australia (ERA) - Collection
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Citation counts: TR Web of Science Citation Count  Cited 90 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 25 Mar 2010, 14:02:17 EST by Jon Swabey on behalf of Institute for Molecular Bioscience