An examination of the overlap between genetic and environmental risk factors for intentional weight loss and overeating

Tracey D. Wade, Susan A. Treloar, Andrew C. Heath and Nicholas G. Martin (2009) An examination of the overlap between genetic and environmental risk factors for intentional weight loss and overeating. International Journal of Eating Disorders, 42 6: 492-497. doi:10.1002/eat.20668


Author Tracey D. Wade
Susan A. Treloar
Andrew C. Heath
Nicholas G. Martin
Title An examination of the overlap between genetic and environmental risk factors for intentional weight loss and overeating
Formatted title
An examination of the overlap between genetic and environmental risk factors for intentional weight loss and overeating
Journal name International Journal of Eating Disorders   Check publisher's open access policy
ISSN 0276-3478
Publication date 2009-02-23
Year available 2009
Sub-type Article (original research)
DOI 10.1002/eat.20668
Volume 42
Issue 6
Start page 492
End page 497
Total pages 6
Editor Julio Licinio
Place of publication United States
Publisher John Wiley & Sons, Inc.
Collection year 2010
Language eng
Subject C1
9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
110311 Medical Genetics (excl. Cancer Genetics)
Abstract Objective: To further our understanding of how intentional weight loss (IWL) and overeating are related, we examined the shared genetic and environmental variance between lifetime IWL and overeating. Method: Interview data were available for 1,976 female twins (both members of 439 and 264 pairs of monozygotic and dizygotic twins, respectively), mean age = 40.61, SD = 4.72. We used lifetime diagnostic data for eating disorders obtained from a semistructured psychiatric telephone interview, examined in a bivariate twin analysis. Both lifetime behaviors were measured on a 3-point scale, where absence of IWL or overeating formed one anchor on the scale and lifetime anorexia nervosa (AN) and bulimia nervosa (BN) formed the opposite anchors, respectively. Results: In line with previous findings, a higher body mass index was significantly associated with the lifetime presence of IWL and/or overeating (odds ratio = 1.13, 95% confidence interval (CI): 1.08-1.19). The best fitting twin model contained additive genetic and nonshared environmental influence influencing both IWL and overeating, with correlations between these influences of 0.61 (95% CI: 0.35-0.92) and 0.24 (95% CI: 0.07-0.42), respectively. Discussion: About 37% of genetic risk factors were considered to overlap between IWL and overeating, and with only 6% of overlap between environmental risk factors. Thus, considerable independence of risk factors was indicated. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Formatted abstract
Objective:
To further our understanding of how intentional weight loss (IWL) and overeating are related, we examined the shared genetic and environmental variance between lifetime IWL and overeating.

Method:
Interview data were available for 1,976 female twins (both members of 439 and 264 pairs of monozygotic and dizygotic twins, respectively), mean age = 40.61, SD = 4.72. We used lifetime diagnostic data for eating disorders obtained from a semistructured psychiatric telephone interview, examined in a bivariate twin analysis. Both lifetime behaviors were measured on a 3-point scale, where absence of IWL or overeating formed one anchor on the scale and lifetime anorexia nervosa (AN) and bulimia nervosa (BN) formed the opposite anchors, respectively.

Results:
In line with previous findings, a higher body mass index was significantly associated with the lifetime presence of IWL and/or overeating (odds ratio = 1.13, 95% confidence interval (CI): 1.08-1.19). The best fitting twin model contained additive genetic and nonshared environmental influence influencing both IWL and overeating, with correlations between these influences of 0.61 (95% CI: 0.35-0.92) and 0.24 (95% CI: 0.07-0.42), respectively.

Discussion:
About 37% of genetic risk factors were considered to overlap between IWL and overeating, and with only 6% of overlap between environmental risk factors. Thus, considerable independence of risk factors was indicated. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2009
Keyword intentional weight loss
environment
genetic
twin
bulimia nervosa
anorexia nervosa
overeating
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 24 Mar 2010, 19:32:40 EST by Amanda Jones on behalf of Medicine - Royal Brisbane and Women's Hospital