Flexible Mx Specification of Various Extended Twin Kinship Designs

Hermine H. Maes, Michael C. Neale, Sarah E. Medland, Matthew C. Keller, Nicholas G. Martin, Andrew C. Heath and Lindon J. Eaves (2009) Flexible Mx Specification of Various Extended Twin Kinship Designs. Twin Research and Human Genetics, 12 1: 26-34. doi:10.1375/twin.12.1.26


Author Hermine H. Maes
Michael C. Neale
Sarah E. Medland
Matthew C. Keller
Nicholas G. Martin
Andrew C. Heath
Lindon J. Eaves
Title Flexible Mx Specification of Various Extended Twin Kinship Designs
Formatted title
Flexible Mx Specification of Various Extended Twin Kinship Designs
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2009-02
Year available 2009
Sub-type Article (original research)
DOI 10.1375/twin.12.1.26
Volume 12
Issue 1
Start page 26
End page 34
Total pages 9
Editor Katherine M Kirk
Nicholas G Martin
Place of publication Australia
Publisher Australian Academic Press Pty. Ltd.
Collection year 2010
Language eng
Subject C1
Abstract The extended twin kinship design allows the simultaneous testing of additive and nonadditive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission (Eaves et al., 1999). It also handles the contribution of these sources of variance to the (co)variation of multiple phenotypes. Keller et al. (2008) extended this comprehensive model for family resemblance to allow or a flexible specification of assortment and vertical transmission. As such, it provides a general framework which can easily be reduced to fit subsets of data such as twin-parent data, children-of-twins data, etc. A flexible Mx specification of this model that allows handling of these various designs is presented in detail and applied to data from the Virginia 30,000. Data on height, body mass index, smoking status, church attendance, and political affiliation were obtained from twins and their families. Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest. Author(s): Hermine H. Maes 1 * | Michael C. Neale 2 | Sarah E. Medland 3 | Matthew C. Keller 4 | Nicholas G. Martin 5 | Andrew C. Heath 6 | Lindon J. Eaves 7
Formatted abstract
The extended twin kinship design allows the simultaneous testing of additive and nonadditive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission (Eaves et al., 1999). It also handles the contribution of these sources of variance to the (co)variation of multiple phenotypes. Keller et al. (2008) extended this comprehensive model for family resemblance to allow or a flexible specification of assortment and vertical transmission. As such, it provides a general framework which can easily be reduced to fit subsets of data such as twin-parent data, children-of-twins data, etc. A flexible Mx specification of this model that allows handling of these various designs is presented in detail and applied to data from the Virginia 30,000. Data on height, body mass index, smoking status, church attendance, and political affiliation were obtained from twins and their families. Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest.

Author(s): Hermine H. Maes 1 * | Michael C. Neale 2 | Sarah E. Medland 3 | Matthew C. Keller 4 | Nicholas G. Martin 5 | Andrew C. Heath 6 | Lindon J. Eaves 7
Keyword extended twin kinship models
twin and family data
Mx
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 24 Mar 2010, 18:16:41 EST by Amanda Jones on behalf of Medicine - Royal Brisbane and Women's Hospital