New insights into the control of secretion

Thorn, Peter (2009) New insights into the control of secretion. Communicative & Integrative Biology, 2 4: 315-317. doi:10.4161/cib.2.4.8262


Author Thorn, Peter
Title New insights into the control of secretion
Journal name Communicative & Integrative Biology   Check publisher's open access policy
ISSN 1942-0889
Publication date 2009-07
Year available 2009
Sub-type Article (original research)
DOI 10.4161/cib.2.4.8262
Open Access Status DOI
Volume 2
Issue 4
Start page 315
End page 317
Total pages 3
Editor Frantisek Baluska
Place of publication United States
Publisher Landes Biosciences
Collection year 2010
Language eng
Subject C1
060602 Animal Physiology - Cell
970106 Expanding Knowledge in the Biological Sciences
Abstract Vesicular secretion is a fundamental process in the body with vesicle fusion releasing vesicle contents to the outside. This process called exocytosis is usually thought of as leading to an all-or-none release of content; regulation of secretory output dependent on regulating the numbers of fused vesicles. However, it is well established that the fusion pore that forms when the vesicle membrane fuses with the cell membrane is dynamic. More recent evidence indicates the dynamic opening and closing, and the size of the fusion pore, are limiting factors to the release of vesicle content. What remains unclear is whether these fusion pore behaviors are under cellular control and therefore relevant to cell physiology.Accumulating evidence over the last two years points to myosin 2 as one regulator of fusion pore behavior. This is interesting since myosin 2 activity is in turn controlled by kinases and phosphatases, well known to be under cellular control. We conclude that fusion pore behavior is likely a genuine control point for vesicle content release. This leads to a model for secretion with secretory output controlled not only by the numbers of vesicles fused but also by the regulation of the behavior of individual vesicles.
Keyword Secretion
Exocytosis
Vesicle
Fusion Pore
Calcium
myosin 2
Actin
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
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Created: Wed, 24 Mar 2010, 15:55:45 EST by Timothy Hazelton on behalf of School of Biomedical Sciences