Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens

Ye, Xianghai, Brown, Stewart R., Nones, Kátia, Coutinho, Luiz L ., Dekkers, Jack C. M. and Lamont, Susan J. (2007) Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens. Genetics Selection Evolution, 39 1: 73-89. doi:10.1051/gse:2006029


Author Ye, Xianghai
Brown, Stewart R.
Nones, Kátia
Coutinho, Luiz L .
Dekkers, Jack C. M.
Lamont, Susan J.
Title Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
Journal name Genetics Selection Evolution   Check publisher's open access policy
ISSN 0999-193X
1297-9686
Publication date 2007-01-01
Sub-type Article (original research)
DOI 10.1051/gse:2006029
Open Access Status DOI
Volume 39
Issue 1
Start page 73
End page 89
Total pages 17
Editor Didier Boichard
Place of publication Paris, France
Publisher EDP sciences
Language eng
Subject 1001 Agricultural Biotechnology
Formatted abstract
Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant (P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
© INRA, EDP Sciences, 2006.
Keyword Myostatin
SNP
Growth
Mortality
Broiler chicken
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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