Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction

Martin, Jennifer H., Connelly, Kim A., Boyle, Andrew, Kompa, Andrew, Zhang, Yuan, Kelly, Darren, Gilbert, Richard E. and Krum, Henry (2010) Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction. International Journal of Cardiology, 143 3: 353-360. doi:10.1016/j.ijcard.2009.03.098

Author Martin, Jennifer H.
Connelly, Kim A.
Boyle, Andrew
Kompa, Andrew
Zhang, Yuan
Kelly, Darren
Gilbert, Richard E.
Krum, Henry
Title Effect of atorvastatin on cardiac remodelling and mortality in rats following hyperglycemia and myocardial infarction
Journal name International Journal of Cardiology   Check publisher's open access policy
ISSN 0167-5273
Publication date 2010-09-03
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.ijcard.2009.03.098
Volume 143
Issue 3
Start page 353
End page 360
Total pages 8
Editor Dr. Chuichi Kawai
Dr. Andrew J. S. Coats
Place of publication Shannon, Ireland
Publisher Elsevier
Collection year 2011
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920103 Cardiovascular System and Diseases
920104 Diabetes
110201 Cardiology (incl. Cardiovascular Diseases)
110306 Endocrinology
Formatted abstract
Effect of HMGCoA Reductase Inhibitors on Cardiac Remodelling and Mortality in Rats. Following Hyperglycemia and Myocardial Infarction.
Aims: The presence of diabetes mellitus (DM) in patients with myocardial infarction (MI) increases mortality, due in part to the presence of known cardiovascular risk factors. However little is known about the impact of DM on cardiac remodelling and on clinical outcomes. We aimed to investigate whether hyperglycaemia may adversely and additionally affect LV remodelling post-MI, and whether the addition of a statin, known to reduce mortality both post MI and in humans with DM, has an effect on these outcomes. Methods: Eight week old Sprague-Dawley rats were allocated to 5 groups - control (non-DM)/sham, control-MI, DM-sham, DM-MI and DM-MI with statin gavage (DM-MI/ATV). Echocardiogram and invasive pressure volume analysis were performed prior to sacrifice for estimation of cardiac function. Tissue was analysed for total cardiac collagen, collagen I and III. Results: Hyperglycaemia in the remodelling period significantly increased mortality (70% survival in the C-MI group vs 27% in the DM-MI group), worsened cardiac function and increased fibrosis. All of these variables were attenuated by the addition of a statin. Conclusion: Hyperglycaemia increased mortality in MI and exacerbated LV remodeling, and this was attenuated with statin use. This study confirms the importance of early and intensive treatment of hyperglycaemia in patients with MI and suggests that in humans with both DM and MI the addition of a statin may be beneficial. © 2009 Elsevier Ireland Ltd.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 22 April 2009.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
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Created: Wed, 24 Mar 2010, 13:41:27 EST by Sarah Macaione on behalf of UQ Diamantina Institute