Pyrrole carboxamidine tryptase inhibitors from leptonychia pubescens

Yang, Lay Kien, Ng, Sok Peng, Flotow, Horst, Yoganathan, K., Daramola, B. O., Soejarto, D. Doel, Buss, Antony D. and Butler, Mark S. (2005) Pyrrole carboxamidine tryptase inhibitors from leptonychia pubescens. Planta Medica, 71 11: 1071-1072. doi:10.1055/s-2005-873111


Author Yang, Lay Kien
Ng, Sok Peng
Flotow, Horst
Yoganathan, K.
Daramola, B. O.
Soejarto, D. Doel
Buss, Antony D.
Butler, Mark S.
Title Pyrrole carboxamidine tryptase inhibitors from leptonychia pubescens
Formatted title
Pyrrole carboxamidine tryptase inhibitors from leptonychia pubescens
Journal name Planta Medica   Check publisher's open access policy
ISSN 0032-0943
1439-0221
Publication date 2005-10
Sub-type Article (original research)
DOI 10.1055/s-2005-873111
Volume 71
Issue 11
Start page 1071
End page 1072
Total pages 2
Place of publication Stuttgart, Germany
Publisher Thieme Medical Publishers
Language eng
Subject 0607 Plant Biology
1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
The root and stem bark extracts of a Nigerian sample of Leptonychia pubescens Keay (Sterculiaceae) were found to inhibit the serine protease tryptase, a potential therapeutic target for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Bioassay-guided isolation led to the identification of 1-β-ribofuranosylbrunfelsamidine as the active component with a tryptase IC50 of 3 μM. Brunfelsamidine was also isolated, but was only weakly active.
Keyword Asthma
Chronic Obstructive Pulmonary Disease
Medicinal Plants
Plant Roots
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 24 Mar 2010, 08:46:27 EST by Ms May Balasaize on behalf of Institute for Molecular Bioscience