Variation in the dysbindin gene and normal cognitive function in three independent population samples

M. Luciano, F. Miyajima, P. A. Lind, T. C. Bates, M. Horan, S. E. Harris, M. J. Wright, W. E. Ollier, C. Hayward, N. Pendleton, A. J. Gow, P. M. Visscher, J. M. Starr, I. J. Deary, N. G. Martin and A. Payton (2009) Variation in the dysbindin gene and normal cognitive function in three independent population samples. Genes, Brain and Behavior, 8 2: 218-227. doi:10.1111/j.1601-183X.2008.00462.x

Author M. Luciano
F. Miyajima
P. A. Lind
T. C. Bates
M. Horan
S. E. Harris
M. J. Wright
W. E. Ollier
C. Hayward
N. Pendleton
A. J. Gow
P. M. Visscher
J. M. Starr
I. J. Deary
N. G. Martin
A. Payton
Title Variation in the dysbindin gene and normal cognitive function in three independent population samples
Journal name Genes, Brain and Behavior   Check publisher's open access policy
ISSN 1601-1848
Publication date 2009-03
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1601-183X.2008.00462.x
Volume 8
Issue 2
Start page 218
End page 227
Total pages 10
Place of publication Denmark
Publisher Wiley-Blackwell Munksgaard
Language eng
Subject C1
Abstract The association between DTNBP1 genotype and cognitive abilities was investigated in three population samples (1054 Scottish, 1806 Australian and 745 English) of varying age. There was evidence in each of the cohorts for association (P < 0.05) to single nucleotide polymorphisms (SNPs) and haplotypes previously shown to relate to cognition. By comparison with previous findings, these associations included measures of memory, and there was at best equivocal evidence of association with general cognitive ability. Of the SNPs typed in all three cohorts, rs2619528 and rs1011313 showed significant association with measures of executive function in two cohorts, rs1018381 showed significant association with verbal ability in one cohort and rs2619522 showed significance/marginal significance with tests of memory, speed and executive function in two cohorts. For all these SNPs, the direction and magnitude of the allelic effects were consistent between cohorts and with previous findings. In the English cohort, a previously untested SNP (rs742105) located in a distinct haplotype block upstream of the other SNPs showed the strongest significance (P < 0.01) for measures of memory but weaker significance for general cognitive ability. Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and the cognitive abilities with which they are associated.
Formatted abstract

Keyword Cognitive ability
normal population
Q-Index Code C1
Q-Index Status Provisional Code
Additional Notes Published Online: 11 Dec 2008

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 32 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 33 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 23 Mar 2010, 19:59:25 EST by Amanda Jones on behalf of Medicine - Royal Brisbane and Women's Hospital