Cell-penetrating peptides and antimicrobial peptides: how different are they?

Henriques, Sónia Troeira, Melo, Manuel Nuno and Castanho, Miguel A. R. B. (2006) Cell-penetrating peptides and antimicrobial peptides: how different are they?. Biochemical journal, 399 1: 1-7. doi:10.1042/BJ20061100


Author Henriques, Sónia Troeira
Melo, Manuel Nuno
Castanho, Miguel A. R. B.
Title Cell-penetrating peptides and antimicrobial peptides: how different are they?
Journal name Biochemical journal   Check publisher's open access policy
ISSN 0006-2936
0264-6021
Publication date 2006-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1042/BJ20061100
Volume 399
Issue 1
Start page 1
End page 7
Total pages 7
Editor Peter Shepherd
Place of publication London, U.K.
Publisher Portland Press
Language eng
Subject 0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
Formatted abstract
Some cationic peptides, referred to as CPPs (cell-penetrating peptides), have the ability to translocate across biological membranes in a non-disruptive way and to overcome the impermeable nature of the cell membrane. They have been successfully used for drug delivery into mammalian cells; however, there is no consensus about the mechanism of cellular uptake. Both endocytic and non-endocytic pathways are supported by experimental evidence. The observation that some AMPs (antimicrobial peptides) can enter host cells without damaging their cytoplasmic membrane, as well as kill pathogenic agents, has also attracted attention. The capacity to translocate across the cell membrane has been reported for some of these AMPs. Like CPPs, AMPs are short and cationic sequences with a high affinity for membranes. Similarities between CPPs and AMPs prompted us to question if these two classes of peptides really belong to unrelated families. In this Review, a critical comparison of the mechanisms that underlie cellular uptake is undertaken. A reflection and a new perspective about CPPs and AMPs are presented.
The Biochemical Society, London ©2006.
Keyword Antimicrobial peptide
Cell-penetrating peptide
Drug delivery
Internalization
Translocation mechanism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 23 Mar 2010, 15:26:17 EST by June Temby on behalf of Institute for Molecular Bioscience