10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum

Yoganathan, K., Rossant, Christine, Ng, Siewbee, Huang, Yicun, Butler, Mark S. and Buss, Antony D. (2003) 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum. Journal of Natural Products, 66 8: 1116-1117. doi:10.1021/np030146m


Author Yoganathan, K.
Rossant, Christine
Ng, Siewbee
Huang, Yicun
Butler, Mark S.
Buss, Antony D.
Title 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum
Formatted title
10-Methoxydihydrofuscin, Fuscinarin, and Fuscin, Novel Antagonists of the Human CCR5 Receptor from Oidiodendron griseum
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2003
Sub-type Article (original research)
DOI 10.1021/np030146m
Volume 66
Issue 8
Start page 1116
End page 1117
Total pages 2
Place of publication Cincinnati, U.S.
Publisher American Chemical Society
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
Two new compounds, 10-methoxydihydrofuscin (1) and fuscinarin (2), and one known compound, fuscin (3), have been isolated from the soil fungus Oidiodendron griseum. These compounds were found to compete effectively with macrophage inflammatory protein (MIP)-1α for binding to human CCR5, an important anti HIV-1 target that interferes with HIV entry into cells. The structures of these compounds were elucidated by spectroscopic methods.
Copyright © 2003 American Chemical Society and American Society of Pharmacognosy
Keyword 10-methoxydihydrofuscin
Benzopyrans
Chemokine CCL4
Heterocyclic Compounds, 3-Ring
Macrophage Inflammatory Proteins
Receptors, CCR5
Fuscinarin
Fuscin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 23 Mar 2010, 14:13:38 EST by Tara Johnson on behalf of Institute for Molecular Bioscience