Successful Use of Gabapentin in Acute Pain Management Following Burn Injury: A Case Series

Gray, Paul, Williams, Bronwyn and Cramond, Tess (2008) Successful Use of Gabapentin in Acute Pain Management Following Burn Injury: A Case Series. Pain Medicine, 9 3: 371-376. doi:10.1111/j.1526-4637.2006.00149.x


Author Gray, Paul
Williams, Bronwyn
Cramond, Tess
Title Successful Use of Gabapentin in Acute Pain Management Following Burn Injury: A Case Series
Journal name Pain Medicine   Check publisher's open access policy
ISSN 1526-2375
Publication date 2008
Sub-type Article (original research)
DOI 10.1111/j.1526-4637.2006.00149.x
Volume 9
Issue 3
Start page 371
End page 376
Total pages 6
Editor Rollin M. Gallagher
Place of publication United States
Publisher Wiley-Blackwell Publishing, Inc.
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
1103 Clinical Sciences
Formatted abstract
Pain after burn injury has multiple qualities, including neuropathic and hyperalgesic elements. This element of the burn patients' pain experience is frequently difficult to manage and contributes significantly to their suffering. The onset may be either immediate or delayed. Gabapentin has established efficacy in the reduction of burn-induced hyperalgesia and allodynia in animal and human experimental burn models. This article reports a case series of six patients who, following admission to hospital with burn injury, described burning dysesthesia at either the injury or graft donor site. These patients were prescribed gabapentin in addition to standard analgesia. The use of gabapentin resulted in a rapid reduction in the severity of the neuropathic element of the pain. The medication was well tolerated, with no severe adverse reactions.

Conclusions. This case series introduces the use of gabapentin as a potentially important therapy in the management of neuropathic pain following burn injury. Further research is required to define the use of gabapentin in this specific setting.
Keyword Burn Injury
Human
Gabapentin
Pain Management
Neuropathic Pain
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Tue, 23 Mar 2010, 10:35:04 EST by Lisa Hennell on behalf of Faculty Of Health Sciences