Natural products — The future scaffolds for novel antibiotics?

Butler, Mark S. and Buss, Antony D. (2006) Natural products — The future scaffolds for novel antibiotics?. Biochemical Pharmacology, 71 7: 919-929. doi:10.1016/j.bcp.2005.10.012

Author Butler, Mark S.
Buss, Antony D.
Title Natural products — The future scaffolds for novel antibiotics?
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 2006-03-30
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bcp.2005.10.012
Volume 71
Issue 7
Start page 919
End page 929
Total pages 11
Editor S. J. Enna
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
Abstract Natural products have played a pivotal role in antibiotic drug discovery with most antibacterial drugs being derived from a natural product or natural product lead. However, the rapid onset of resistance to most antibacterial drugs diminishes their effectiveness considerably and necessitates a constant supply of new antibiotics for effective treatment of infections. The natural product templates of actinonin, pleuromutilin, ramoplanin and tiacumicin B, which are compounds undergoing clinical evaluation, represent templates not found in currently marketed antibacterial drugs. In addition, the new templates present in the recently discovered lead antibacterials arylomycin, GE23077, mannopeptimycin, muraymycin/caprazamycin, nocathiacin and ECO-0501, are discussed. Despite extensive efforts to identify antibiotic leads from molecular targets, only the peptide deformylase inhibitor LBM-415 is currently in clinical trials. It is proposed that new antibacterial assays which combine cell-based screening with molecular targets could offer better prospects for lead discovery.
Keyword Natural product
Clinical trial
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Special Issue on Antibacterials

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 168 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 22 Mar 2010, 14:41:15 EST by June Temby on behalf of Institute for Molecular Bioscience