The role of natural product chemistry in drug discovery

Butler, Mark S. (2004) The role of natural product chemistry in drug discovery. Journal of Natural Products, 67 12: 2141-2153. doi:10.1021/np040106y

Author Butler, Mark S.
Title The role of natural product chemistry in drug discovery
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2004-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1021/np040106y
Volume 67
Issue 12
Start page 2141
End page 2153
Total pages 13
Editor A. Kinghorn Douglas
Place of publication Cincinnati, OH, U.S.A.
Publisher American Chemical Society
Language eng
Subject 0601 Biochemistry and Cell Biology
0607 Plant Biology
Formatted abstract
Although traditionally natural products have played an important role in drug discovery, in the past few years most Big Pharma companies have either terminated or considerably scaled down their natural product operations. This is despite a significant number of natural product-derived drugs being ranked in the top 35 worldwide selling ethical drugs in 2000, 2001, and 2002. There were 15 new natural product-derived drugs launched from 2000 to 2003, as well as 15 natural product-derived compounds in Phase III clinical trials or registration at the end of 2003. Recently, there has been a renewed interest in natural product research due to the failure of alternative drug discovery methods to deliver many lead compounds in key therapeutic areas such as immunosuppression, anti-infectives, and metabolic diseases. To continue to be competitive with other drug discovery methods, natural product research needs to continually improve the speed of the screening, isolation, and structure elucidation processes, as well addressing the suitability of screens for natural product extracts and dealing with issues involved with large-scale compound supply.
© 2004 American Chemical Society and American Society of Pharmacognosy.

Keyword Natural products
Natural product-derived drugs
Alternative drug discovery methods
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 500 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 22 Mar 2010, 13:02:00 EST by June Temby on behalf of Institute for Molecular Bioscience