New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells

Yap, Sook Peng, Shen, Ping, Butler, Mark S., Gong, Yinhan, Loy, Chong Jin and Yong, Eu Leong (2005) New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells. Planta Medica, 71 2: 114-119. doi:10.1055/s-2005-837776


Author Yap, Sook Peng
Shen, Ping
Butler, Mark S.
Gong, Yinhan
Loy, Chong Jin
Yong, Eu Leong
Title New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells
Formatted title
New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells
Journal name Planta Medica   Check publisher's open access policy
ISSN 0032-0943
1439-0221
Publication date 2005-02-01
Sub-type Article (original research)
DOI 10.1055/s-2005-837776
Volume 71
Issue 2
Start page 114
End page 119
Total pages 6
Editor Adolf Nahrstedt
Place of publication Stuttgart, Germany
Publisher Thieme
Language eng
Subject 0607 Plant Biology
1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
Estrogens maintain female sexual health. The hormone also drives the growth of estrogen receptor (ER) positive breast tumors, and ER modulators, like tamoxifen, are used to reduce tumor recurrence. To identify phytoestrogens with possible health benefits, we screened several Traditional Chinese Medicines and encountered an extract from the leaves of Epimedium brevicornum (EB), with strong (EC50 : 1.3 μg/mL) and specific ER-stimulatory activity. It increased estrogen-responsive human breast cancer cell proliferation at low doses, but paradoxically caused profound inhibition of growth at higher doses. Using bioassay-guided fractionation, we isolated and characterized a new prenylflavone, breviflavone B, which exerted biphasic stimulatory and inhibitory effects on breast cancer cell proliferation, mimicking the effects of EB. In contrast to estradiol and genistein, high doses (> 2 μM) of breviflavone B almost eliminated ERα protein; a process that may be mediated through increased proteasome degradation. Pre-clinical studies are needed to explore whether these prenylflavones are of value in estrogen-deficiency states and for prophylaxis of breast cancer.
© Georg Thieme Verlag KG Stuttgart · New York.
Keyword Epimedium brevicornum
Berberidaceae
Prenylflavone
Estrogen
Receptor
Anti-proliferation
Breast - cancer
References - Berberidaceae - prenylflavone - estrogen - receptor - anti-proliferation - breast - cancer
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 22 Mar 2010, 22:37:02 EST by June Temby on behalf of Institute for Molecular Bioscience