Gravity-dependent ventilation distribution in rats measured with electrical impedance tomography

Rooney, D, Friese, M, Fraser, JF, Dunster, KR and Schibler, A (2009) Gravity-dependent ventilation distribution in rats measured with electrical impedance tomography. Physiological Measurement, 30 10: 1075-1085. doi:10.1088/0967-3334/30/10/008


Author Rooney, D
Friese, M
Fraser, JF
Dunster, KR
Schibler, A
Title Gravity-dependent ventilation distribution in rats measured with electrical impedance tomography
Journal name Physiological Measurement   Check publisher's open access policy
ISSN 0967-3334
1361-6579
Publication date 2009-09-09
Year available 2009
Sub-type Article (original research)
DOI 10.1088/0967-3334/30/10/008
Volume 30
Issue 10
Start page 1075
End page 1085
Total pages 11
Place of publication United Kingdom
Publisher Institute of Physics Publishing
Collection year 2010
Language eng
Subject C1
110320 Radiology and Organ Imaging
090303 Biomedical Instrumentation
321027 Respiratory Diseases
320601 Human Biophysics
Abstract Ventilation in larger animals and humans is gravity dependent and mainly distributed to the dependent lung. Little is known of the effect of gravity on ventilation distribution in small animals such as rodents. The aim of this study was to investigate gravity-dependent ventilation distribution and regional filling characteristics in rats. Ventilation distribution and regional lung filling were measured in six rats using electrical impedance tomography (EIT). Measurements were performed in four body positions (supine, prone, left and right lateral), and all animals were ventilated with increasing tidal volumes from 3 to 8 mL kg−1. The effect of gravity on regional ventilation distribution was assessed with profiles of relative impedance change and calculation of the geometric centre. Regional filling was measured by calculating the slope of the plot of regional versus global relative impedance change on a breath-by-breath basis. Ventilation was significantly distributed to the non-dependent lung regardless of body position and tidal volume used. The geometric centre was located in the dependent lung in all but prone position. The regional filling characteristics followed an anatomical pattern with the posterior and the right lung generally filling faster. Gravity had little impact on regional filling. Ventilation distribution in rats is gravity dependent, whereas regional filling characteristics are dependent on anatomy.
Keyword Electrical Impedance Tomography
Rats
Ventilation
Biological physics
Medical physics
Instrumentation and measurement
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
Centre for Advanced Imaging Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 22 Mar 2010, 22:34:48 EST by Lisa Hennell on behalf of Centre For Magnetic Resonance