A new model for utilising chemical diversity from natural sources

Buss, Antony D. and Butler, Mark S. (2004) A new model for utilising chemical diversity from natural sources. Drug Development Research, 62 4: 362-370. doi:10.1002/ddr.10389

Author Buss, Antony D.
Butler, Mark S.
Title A new model for utilising chemical diversity from natural sources
Journal name Drug Development Research   Check publisher's open access policy
ISSN 1098-2299
Publication date 2004-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/ddr.10389
Volume 62
Issue 4
Start page 362
End page 370
Total pages 9
Editor Michael Williams
Place of publication New York, U.S.A
Publisher Wiley-Liss
Language eng
Subject 1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
Although combinatorial chemistry technology has enabled large libraries of compounds to be screened for biological activity and synthetic modifications to be effected rapidly, the reality is that quality leads and development candidates for many drug targets still prove difficult to find. This is particularly relevant to antiinfective, oncology, and immunomodulation targets and also those involving protein-protein interactions. In the past, natural products have led to excellent drugs for precisely these therapeutic areas, but the difficulties of identifying and utilising such compounds compared to less complex molecules synthesised using combinatorial chemistry techniques then led many to question their value in modern-day drug discovery. In fact, in the early 1990s, a significant number of pharmaceutical companies reduced or even terminated the natural product-based drug discovery activities that had served them so well in the past. Nevertheless a renaissance appears to be at hand. The pressing need to fill drug development pipelines, combined with attractive outsourcing opportunities, have prompted many of the very same companies to reevaluate the utility of natural products as sources of novel drug leads. Through a judicious combination of new technologies and compelling business model, at least one Singapore-based company is offering cost-effective solutions for accessing the unique chemical diversity found in Nature.
© 2004 Wiley-Liss, Inc.
Keyword Natural products
High-throughput screening
Business model
Drug discovery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Mon, 22 Mar 2010, 12:12:56 EST by June Temby on behalf of Institute for Molecular Bioscience