Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy

McIntyre, H. David, Chang, Allan M., Callaway, Leonie K., Cowley, David M., Dyer, Alan R., Radaelli, Tatjana, Farrell, Kristen A., Huston-Presley, Larraine, Amini, Saeid B., Kirwan, John P. and Catalano, Patrick M. (2010) Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy. Diabetes Care, 33 2: 356-360. doi:10.2337/dc09-1196

Author McIntyre, H. David
Chang, Allan M.
Callaway, Leonie K.
Cowley, David M.
Dyer, Alan R.
Radaelli, Tatjana
Farrell, Kristen A.
Huston-Presley, Larraine
Amini, Saeid B.
Kirwan, John P.
Catalano, Patrick M.
Title Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy
Journal name Diabetes Care   Check publisher's open access policy
ISSN 0149-5992
Publication date 2010-02
Year available 2009
Sub-type Article (original research)
DOI 10.2337/dc09-1196
Volume 33
Issue 2
Start page 356
End page 360
Total pages 5
Place of publication Alexandria, VA, United States
Publisher American Diabetes Association
Collection year 2011
Language eng
Formatted abstract
OBJECTIVE - The objective of this study was to determine maternal hormonal and metabolic factors associated with insulin sensitivity in human pregnancy.
This was a prospective observational crosssectional study of 180 normal pregnant women, using samples collected at the time of a blinded oral glucose tolerance test (OGTT) between 24 and 32 weeks' gestation as an ancillary to the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. The study was conducted at two public university teaching hospitals, Cleveland, Ohio, and Brisbane, Australia. Fasting maternal serum cholesterol, triglycerides, free fatty acids, insulin, leptin, tumor necrosis factor-α, placental growth hormone (PGH), insulin-like growth factors (IGFs) 1 and 2, and insulinlike growth factor binding proteins (IGFBPs) 1 and 3 were assayed. Correlation and multiple regression analyses were used to determine factors associated with maternal insulin sensitivity (IS) estimated using both OGTT-derived (ISOGTT) and fasting (using the homeostasis model assessment [HOMA]; ISHOMA) insulin and glucose concentrations.
Insulin sensitivity correlated (r = x and y for ISOGTT and ISHOMA, respectively) with fasting maternal serum leptin (-0.44 and -0.52), IGFBP1 (0.42 and 0.39), and triglycerides (-0.31 and -0.27). These factors were significantly associated with insulin sensitivity in multiple regression analyses (adjusted R2 0.44 for ISOGTT and ISHOMA). These variables explained more than 40% of the variance in estimates of insulin sensitivity.
- Maternal hormonal and metabolic factors related to the placenta, adipose tissue, and the growth hormone axis are associated with the variation in insulin sensitivity seen during normal human pregnancy.
© 2010 by the American Diabetes Association.
Keyword Gestational diabetes mellitus
Longitudinal changes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online October 30, 2009 Published under 'Pathophysiology/Complications'

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2011 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 34 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 21 Mar 2010, 00:08:08 EST