Non-coding RNAs in mammalian sexual development

McFarlane, L. and Wilhelm, D. (2010) Non-coding RNAs in mammalian sexual development. Sexual Development, 3 6: 302-316. doi:10.1159/000284688


Author McFarlane, L.
Wilhelm, D.
Title Non-coding RNAs in mammalian sexual development
Journal name Sexual Development   Check publisher's open access policy
ISSN 1661-5425
1661-5433
Publication date 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1159/000284688
Volume 3
Issue 6
Start page 302
End page 316
Total pages 15
Place of publication Basel, Switzerland
Publisher S. Karger
Collection year 2011
Language eng
Abstract The present decade is witnessing a paradigm shift in our understanding of gene regulation. RNA, once relegated to an intermediary between DNA and protein, has emerged as a key contributor in the coordination of complex developmental pathways. For sexually reproducing organisms, propagation of the species is accomplished via an elaborate sexual phenotype. In mammals this consists of a highly complex cell lineage that has the capacity for intricate self-differentiation whilst maintaining the potential to generate all cell types upon fertilization. In addition, mammals possess a diverse range of somatic reproductive tissues and organs that often undergo dynamic morphological changes in response to a variety of external and internal cues. Although the protein component required to mediate these processes continues to be vigorously investigated, it is becoming increasingly apparent that an understanding of the non-coding RNA (ncRNA) component is required to develop a comprehensive picture of mammalian sexual development. Copyright © 2010 S. Karger AG, Basel
Keyword miRNA
Non-coding RNA
Ovary
piRNA
Sexual development
siRNA
Testis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Sun, 21 Mar 2010, 00:00:43 EST