Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression

Middeldorp, CM, Sullivan, PF, Wray, NR, Hottenga, JJ, de Geus, EJC, van den Berg, M, Montgomery, GW, Coventry, WL, Statham, DJ, Andrews, G, Slagboom, PE, Boomsma, DI and Martin, NG (2008) Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B 3: 352-358. doi:10.1002/ajmg.b.30817


Author Middeldorp, CM
Sullivan, PF
Wray, NR
Hottenga, JJ
de Geus, EJC
van den Berg, M
Montgomery, GW
Coventry, WL
Statham, DJ
Andrews, G
Slagboom, PE
Boomsma, DI
Martin, NG
Title Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
Formatted title
Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
Journal name American Journal of Medical Genetics Part B: Neuropsychiatric Genetics   Check publisher's open access policy
ISSN 1552-4841
Publication date 2008-07-09
Year available 2008
Sub-type Article (original research)
DOI 10.1002/ajmg.b.30817
Volume 150B
Issue 3
Start page 352
End page 358
Total pages 7
Place of publication United States
Publisher John Wiley & Sons, Inc.
Language eng
Subject C1
Abstract Abstract It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD (total N = 278). Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LOD-score of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2. © 2008 Wiley-Liss, Inc.
Formatted abstract
Abstract
It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD (total N = 278). Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LOD-score of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2. © 2008 Wiley-Liss, Inc.
Keyword Genome-wide linkage
Serotonin transporter gene
Family study
Genetics
Depression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Published Online: 9 Jul 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Fri, 19 Mar 2010, 16:35:20 EST by Amanda Jones on behalf of Medicine - Royal Brisbane and Women's Hospital