IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host

Liu, Xiao Song, Leerberg, Joanne, MacDonald, Kelli, Leggatt, Graham and Frazer, Ian (2009) IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. The Jounral of Immunology, 183 1: 51-58. doi:10.4049/jimmunol.0802047


Author Liu, Xiao Song
Leerberg, Joanne
MacDonald, Kelli
Leggatt, Graham
Frazer, Ian
Title IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host
Journal name The Jounral of Immunology   Check publisher's open access policy
ISSN 0022-1767
Publication date 2009-06-17
Year available 2009
Sub-type Article (original research)
DOI 10.4049/jimmunol.0802047
Volume 183
Issue 1
Start page 51
End page 58
Total pages 8
Editor J.M. Boss
Place of publication United States
Publisher The American Association of Immunologists
Collection year 2010
Language eng
Subject 970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920109 Infectious Diseases
1107 Immunology
Abstract Ags characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated, and consequent generation of regulatory CD4+ T cells can inhibit induction of desired effector CD8 T cell responses. IL-10 produced in response to ongoing Ag exposure inhibits generation of CD8 T cells in an Ag-experienced host. We now show that this IL-10 is produced by Ag experienced CD4+ glucocorticoid-induced tumor necrosis factor receptor+ T cells that also secrete IFN-{gamma} upon antigenic stimulation, that IL-10 secretion by these cells is enhanced through IFN-{gamma} signaling, and, unexpectedly, that IFN-{gamma} signaling is required for inhibition of generation of Ag-specific CD8 T cell responses in an Ag-experienced host. Systemic inhibition of both IL-10 and IFN-{gamma} at the time of immunization may therefore facilitate induction of effective immunotherapeutic responses against tumor specific and viral Ags.
Keyword Secreting
Antigen
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Sat, 20 Mar 2010, 00:01:53 EST by Sarah Macaione on behalf of UQ Diamantina Institute